Potassium Hydroxide → N-(2,3-dihydroxypropyl)-N-tetradecyl-2-hydroxyoctanamide

HRID 2260090

反応式

HRID 2260090 の反応式
[OH:1][CH:2]([CH2:19][OH:20])[CH2:3][NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH-].[K+].C[O:24][C:25](=O)[CH:26]([OH:33])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>>[OH:1][CH:2]([CH2:19][OH:20])[CH2:3][N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:25](=[O:24])[CH:26]([OH:33])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

参加物

4

反応物 3

HCID 14797Potassium HydroxideHCID 10487462Methyl 2-hydroxyoctanoateHCID 189993733-(Tetradecylamino)propane-1,2-diol

生成物 1

HCID 18999341N-(2,3-dihydroxypropyl)-N-tetradecyl-2-hydroxyoctanamide

実験手順

N-(2,3-dihydroxypropyl)-N-tetradecylamine (1.0 g, 0.0035 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.667 g, 0.0038 mole) was added dropwise to the reaction. The reaction was heated under vacuum for 5 hours. A waxy off-white solid was obtained (crude yield=1.33 g). The waxy solid was recrystalized from hot hexane (yield=0.4 g).

後処理

  1. additionwas added dropwise to the reaction
  2. temperatureThe reaction was heated under vacuum for 5 hours
  3. customA waxy off-white solid was obtained (crude yield=1.33 g)
  4. customThe waxy solid was recrystalized from hot hexane (yield=0.4 g)

出典と根拠

ORDレコード
ord-d7151c055903496fa8bf8b5892904c27
出典データセット
uspto-grants-1995_12
特許番号
US05476671

関連ノート

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