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Benzyl Chloride → 1-(Phenylmethyl)cycloheptanecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | Cycloheptanecarbonitrile | HCID 96653 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(Phenylmethyl)cycloheptanecarbonitrile | HCID 18999624 | 55.8% |
反応手順
Obtained by operating as in example 27b, from 195 mmoles of lithiated diisopropylamine (25.6 g (252.9 mmoles) of diisopropylamine treated with 122 ml (195 mmoles) of n-butyllithium 1.6M in hexane) in 300 ml of dry tetrahydrofuran, 24 g (195 mmoles) of commercial cycloheptanecarbonitrile and 24.6 g (195 mmoles) of benzyl chloride. After distillation, there is obtained 23.2 g (yield=55.8%) of a yellow viscous liquid. b.p.16 =190°-7° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05476846 |
| 出典データセット | uspto-grants-1995_12 |
| ORD ID | ord-e1b3194c3ca74d3a9a212a2646cf2902 |
| 出典メモ | uspto-grants-1995_12 |