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Potassium Carbonate → 4-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromo-1-propanol | HCID 12308 | — |
| 反応物 | 6-Fluoro-1-methyl-3-(piperidin-4-yl)-1H-indazole | HCID 14032608 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine | HCID 18998799 | 36% |
反応手順
A mixture of 4-(6-fluoro-1-methyl-1H-indazol-3-yl)piperidine (5.0 g; 0.02 mol), potassium carbonate (8.28 g; 0.06 mol), 3-bromopropanol (2.98 g; 0.02 mol) and acetone (100 ml) was stirred and refluxed for 20 h. The reaction mixture was filtered, concentrated in vacuo and purified by chromatography on silica gel 60 with ethyl acetate:methanol (8:2, v/v) as eluent. Concentration of the appropriate fractions afforded 2.1 g (34%) of 4-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05478845 |
| 出典データセット | uspto-grants-1995_12 |
| ORD ID | ord-6e51e86428c74d6698dd3a17c42a38e1 |
| 出典メモ | uspto-grants-1995_12 |