Diethyl 2-butyl-3-(phenylamino)-2-butenedioate → 4-[(3-Butyl-4-quinolinyl)-methyl]-benzonitrile

HRID 2260815ノート

反応式

HRID 2260815 の反応式
[CH2:1]([C:5](=[C:11]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C(OCC)=O)[C:6](OCC)=O)[CH2:2][CH2:3][CH3:4]>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH2:6]([C:5]1[CH:11]=[N:17][C:18]2[C:19]([C:1]=1[CH2:2][C:3]1[CH:4]=[CH:6][C:5]([C:11]#[N:17])=[CH:1][CH:2]=1)=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:19][CH2:18][CH3:23]

参加物

3

反応物 1

HCID 67576867Diethyl 2-butyl-3-(phenylamino)-2-butenedioate

生成物 1

HCID 189990804-[(3-Butyl-4-quinolinyl)-methyl]-benzonitrile収率 154.8%

試薬・触媒・溶媒 1

HCID 7583Diphenyl Ether溶媒

反応条件

温度
250 °C

実験手順

A mixture of 2.5 g of the product of Step B and 30 ml of diphenylether was heated for 30 minutes in a bath at 250° C. The mixture was allowed to return to ambient temperature, separated and washed with pentane to obtain 1.82 g of the desired product.

後処理

  1. customto return to ambient temperature
  2. customseparated
  3. washwashed with pentane

出典と根拠

ORDレコード
ord-5150924a31d644f89bee5df9c6777f3a
出典データセット
uspto-grants-1995_12
特許番号
US05478938

反応ノート

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