Acetone → 1-Methoxy-3-(methylsulfonyl)benzene

HRID 2260943

反応式

HRID 2260943 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5](SC)[CH:6]=[CH:7][CH:8]=1.O[O:12][S:13]([O-:15])=O.[K+].[CH3:17]C(C)=O>O>[CH3:17][S:13]([C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1)(=[O:15])=[O:12]

参加物

5

反応物 3

HCID 180AcetoneHCID 2811823-MethoxythioanisoleHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 2596501-Methoxy-3-(methylsulfonyl)benzene収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 3-methoxythioanisole (3.084 g, 20 mmol) in 300 mL acetone was added a solution of oxone (30.74 g, 50 mmol) in 125 mL water, resulting in the formation of a white precipitate. Stirring continued overnight, and the solid was filtered off and washed with acetone. Filtrate was concentrated to remove acetone. Aqueous layer was extracted with EtOAc (2×200 mL) and dried over Na2SO4. The solvent was removed to give 1-methanesulfonyl-3-methoxy benzene (3.68 g, 98%) as oil.

後処理

  1. customresulting in the formation of a white precipitate
  2. filtrationthe solid was filtered off
  3. washwashed with acetone
  4. concentrationFiltrate was concentrated
  5. customto remove acetone
  6. extractionAqueous layer was extracted with EtOAc (2×200 mL)
  7. dry with materialdried over Na2SO4
  8. customThe solvent was removed

出典と根拠

ORDレコード
ord-a092a170314e42e3a7d10ec239a28001
出典データセット
uspto-grants-2010_12
特許番号
US07846915B2

関連ノート

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