Dimethylamine → 4-(Dimethylamino)quinazoline-6-carbaldehyde

HRID 2261087

反応式

HRID 2261087 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:12]=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:14][NH:15][CH3:16]>O1CCOCC1.O>[CH3:14][N:15]([CH3:16])[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:12]=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1

参加物

5

反応物 2

HCID 674DimethylamineHCID 574696394-Chloroquinazoline-6-carbaldehyde

生成物 1

HCID 574696434-(Dimethylamino)quinazoline-6-carbaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

4-Chloro-quinazoline-6-carbaldehyde (200 mg, 1 mmol) was dissolved in 10 ml dioxane. To this solution was added a solution of dimethylamine in water (Seq.). The mixture was stirred during 2 h at r.t. Evaporation of the solvents and remaining amine under high vacuum afforded pure 4-Dimethylamino-quinazoline-6-carbaldehyde as a yellow solid, which was used for the next step without further purification (190 mg=91%).

後処理

  1. customEvaporation of the solvents

出典と根拠

ORDレコード
ord-19e89ecccf8b403fa39709139227c3eb
出典データセット
uspto-grants-2010_12
特許番号
US07846925B2

関連ノート

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