2-Fluoro-4-hydroxybenzoic Acid → (2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

反応式

[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][NH:20]1>>[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:20]1[CH2:21][CH2:22][CH2:23][C@H:19]1[CH2:18][N:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[CH3:12])=[O:6]

参加物

反応物 2

HCID 27833982-Fluoro-4-hydroxybenzoic Acid

HCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

生成物 1

HCID 11960537(2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

実験手順

The title compound is prepared in a manner substantially analogous to Procedure A from 2-Fluoro-4-hydroxy-benzoic acid and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 307.3.

出典と根拠

ORDレコード: ord-93f834fc51db462db1f8c82191f3ea10
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07846950B2

反応ノート

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