(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → (2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

反応式

[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:6]

参加物

反応物 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine

HCID 27833982-Fluoro-4-hydroxybenzoic Acid

生成物 1

HCID 59259534(2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

実験手順

The title compound is prepared in a manner substantially analogous to Procedure A from 2-fluoro-4-hydroxybenzoic acid [CAS 65145-13-3] and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 293.1

出典と根拠

ORDレコード: ord-096aa8261a8449c787d33cc80d5c7ee5
出典データセット: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07846950B2

反応ノート

読み込み中…