Dichloromethane → 3-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride

HRID 226127ノート

反応式

HRID 226127 の反応式
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19](O)=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1.[Cl:23]CCl>CN(C)C=O>[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([Cl:23])=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 670195353-(3-p-Tolylsulfamoyl-phenyl)-acrylic acid

生成物 1

HCID 739893963-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride収率 99.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

反応条件

温度
40 °C

実験手順

To a suspension of 3-(3-p-tolylsulfamoyl-phenyl)-acrylic acid (5d) (0.75 g, 2.36 mmol) in dichloromethane (10.0 ml) oxalyl chloride (0.62 ml, 7.08 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.79 g).

後処理

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ec7431507b994fe788d62ba58e7326dd
出典データセット
uspto-grants-2009_07
特許番号
US07557140B2

反応ノート

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