Carbon tetrabromide → 861135-68-4

HRID 2261324ノート

反応式

HRID 2261324 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[O:7][N:6]=[C:5]([CH2:8]O)[CH:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(OCC)C>[Br:32][CH2:8][C:5]1[CH:4]=[C:3]([C:2]([F:11])([F:10])[F:1])[O:7][N:6]=1

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 153652003-Isoxazolemethanol,5-(trifluoromethyl)-(9CI)

生成物 1

HCID 57736368861135-68-4収率 33.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

2.47 g of (5-trifluoromethyl-isoxazol-3-yl)methanol was dissolved in 80 ml of diethyl ether, and 6.56 g of triphenylphosphine and 8.9 g of carbon tetrabromide were then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was subjected to silica gel column chromatography to obtain 1.14 g of 3-(bromomethyl)-5-trifluoromethylisoxazole.

出典と根拠

ORDレコード
ord-11e19dca3f704f609044ec36d8cb4281
出典データセット
uspto-grants-2010_12
特許番号
US07846956B2

反応ノート

読み込み中…