2-tert-Butyl-4-methylphenol → 2-Bromo-4-methyl-6-tert-butylphenol
反応式
[C:1]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[OH:12])([CH3:4])([CH3:3])[CH3:2].[Br:13]Br>C(Cl)Cl>[C:1]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([Br:13])[C:6]=1[OH:12])([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
2-t-Butyl-4-methylphenol (10 g, 60.8 mmol) is dissolved in CH2Cl2 (300 mL). Bromine (3.1 mL, 60.8 mmol) is added dropwise to the solution. After 20 minutes, the crude mixture is washed with H2O, dried over MgSO4, filtered and rotovapped to give yellow oil: 12.6 g, 85%. 1H NMR (CDCl3) δ: 1.402 (s, 9H, t-Bu), 2.267 (s, 3H, CH3), 5.640 (s, 1H, OH), 7.017 (s, 1H, Ar), 7.167 (s, 1H, Ar).
後処理
- washthe crude mixture is washed with H2O
- dry with materialdried over MgSO4
- filtrationfiltered
- customto give yellow oil
出典と根拠
- ORDレコード
- ord-797882cd13494660a7d156002f0b2b14
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07847099B2
反応ノート
読み込み中…