Hydrochloric Acid → 2-(4-Amino-3-nitrobenzoyl)benzoic acid

HRID 2261924ノート

反応式

HRID 2261924 の反応式
Cl[C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].Cl.[OH-].[NH4+:24]>>[NH2:24][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 665622-(4-Chloro-3-nitrobenzoyl)benzoic acid

生成物 1

HCID 27975222-(4-Amino-3-nitrobenzoyl)benzoic acid収率 98%

実験手順

A solution of 2-(4-chloro-3-nitrobenzoyl)benzoic acid (5.0 g, 16.36 mmol) was heated to reflux in 28-30% aq. ammonium hydroxide (100 mL) for 18 h. The solution was cooled to room temperature followed by addition of 6N aq. hydrochloric acid until pH to 7. The precipitated yellow solid was collected by filtration and washed with water then dried in vacuo to provide 2-[(4-amino-3-nitrophenyl)carbonyl]benzoic acid (4.60 g, 98%). MS (EI) for C14H10N2O5: 288 (MH+).

後処理

  1. filtrationThe precipitated yellow solid was collected by filtration
  2. washwashed with water
  3. customthen dried in vacuo

出典と根拠

ORDレコード
ord-106c24324f614c2690e00df2af337fbd
出典データセット
uspto-grants-2010_12
特許番号
US07846959B2

反応ノート

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