Methanol → Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate

HRID 2261925ノート

反応式

HRID 2261925 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].S(=O)(=O)(O)O.[CH3:27]O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([O:14][CH3:27])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27975222-(4-Amino-3-nitrobenzoyl)benzoic acid

生成物 1

HCID 14994663Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate

実験手順

A solution of 2-[(4-amino-3-nitrophenyl)carbonyl]benzoic acid (4.60 g, 16.00 mmol) in methanol (300 mL) in the presence of catalytic amount of cc. sulfuric acid was heated to reflux for 18 h. The solution was cooled to room temperature and the solvent was evaporated. The yellow precipitate formed was collected by filtration, washed with water and dried in vacuo to provide methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate (4.8 g, quantitative). MS (EI) for C15H12N2O5: 301 (MH+).

後処理

  1. temperatureto reflux for 18 h
  2. customthe solvent was evaporated
  3. customThe yellow precipitate formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-7b5ba5cfa6504cbaab1410ddcbd82788
出典データセット
uspto-grants-2010_12
特許番号
US07846959B2

反応ノート

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