Methanol → 2-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

HRID 2262263ノート

反応式

HRID 2262263 の反応式
CS[CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].O[O:18][S:19]([O-:21])=O.[K+].[CH3:23]O>O>[CH3:23][S:19]([CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])(=[O:21])=[O:18]

参加物

5

反応物 3

HCID 887MethanolHCID 134589972-[3-(Methylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dioneHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 134590592-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a solution of 2-(3-methylsulfanyl-propyl)-isoindole-1,3-dione (440 mg) in methanol (10 mL) was added a solution of oxone (1.73 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(3-methanesulfonyl-propyl)-isoindole-1,3-dione as a white solid.

後処理

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-ec63c011e2fb47069916147c21f7e919
出典データセット
uspto-grants-2010_12
特許番号
US07846929B2

反応ノート

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