Dodecanoyl chloride → HCID 68778247、化合物

HRID 2262339

反応式

HRID 2262339 の反応式
[NH:1]1[CH:5]([C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7])[CH2:4][CH2:3][C:2]1=[O:12].[C:13](Cl)(=[O:25])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:13]([N:1]1[CH:5]([C:6]([O:8][CH:9]([CH3:10])[CH3:11])=[O:7])[CH2:4][CH2:3][C:2]1=[O:12])(=[O:25])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

参加物

5

反応物 3

HCID 8166Dodecanoyl chlorideHCID 8471TriethylamineHCID 97590Isopropyl 5-oxo-DL-prolinate

生成物 1

HCID 68778247HCID 68778247、化合物収率 17.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

10.0 g of isopropyl 2-pyrrolidone-5-carboxylate was dissolved in 58.4 g of toluene, and 13.04 g of lauroyl chloride was added thereto. Further, 6.03 g of triethylamine was dropwise added, and reacted under reflux for 2 hours. Toluene was concentrated under reduced pressure, then the reaction mixture was purified through silica gel column chromatography (hexane/ethyl acetate=5/1 to 3/1) to obtain 3.69 g of isopropyl N-lauroyl-2-pyrrolidone-5-carboxylate.

後処理

  1. customreacted
  2. temperatureunder reflux for 2 hours
  3. concentrationToluene was concentrated under reduced pressure
  4. customthe reaction mixture was purified through silica gel column chromatography (hexane/ethyl acetate=5/1 to 3/1)

出典と根拠

ORDレコード
ord-4f4cae3833c14c9d80bc5490ab437f94
出典データセット
uspto-grants-2010_12
特許番号
US07850955B2

関連ノート

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