化工社化工社 化学情報印刷レポート · 研究参考用
Dodecanoyl chloride → isopropyl N-lauroyl-2-pyrrolidone-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dodecanoyl chloride | HCID 8166 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Isopropyl 5-oxo-DL-prolinate | HCID 97590 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | isopropyl N-lauroyl-2-pyrrolidone-5-carboxylate | HCID 68778247 | 17.9% |
反応手順
10.0 g of isopropyl 2-pyrrolidone-5-carboxylate was dissolved in 58.4 g of toluene, and 13.04 g of lauroyl chloride was added thereto. Further, 6.03 g of triethylamine was dropwise added, and reacted under reflux for 2 hours. Toluene was concentrated under reduced pressure, then the reaction mixture was purified through silica gel column chromatography (hexane/ethyl acetate=5/1 to 3/1) to obtain 3.69 g of isopropyl N-lauroyl-2-pyrrolidone-5-carboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07850955B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-4f4cae3833c14c9d80bc5490ab437f94 |
| 出典メモ | uspto-grants-2010_12 |