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4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide → 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide | HCID 408891 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide | HCID 77374 | 106.4% |
反応手順
5.7 g (19.3 mmol) of 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is dissolved in 120 ml of tetrahydrofuran:ethanol 1:1>mixed with 2 g of palladium on carbon (10%×50% water) and hydrogenated for 1 hour at room temperature and normal pressure. After being drawn off on diatomaceous earth and after concentration by evaporation, 5.45 g of 4-amino-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07850948B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-fec49c96a0654ddaa3d16ec6f4872d02 |
| 出典メモ | uspto-grants-2010_12 |