(R)-N-Boc-2-hydroxymethylmorpholine → (R)-4-Methyl-2-(hydroxymethyl)morpholine

HRID 2262475ノート

反応式

HRID 2262475 の反応式
C(O[C:6]([N:8]1[CH2:13][CH2:12][O:11][C@@H:10]([CH2:14][OH:15])[CH2:9]1)=O)(C)(C)C.C(OC(N1CCO[C@H](CO)C1)=O)(C)(C)C>>[CH3:6][N:8]1[CH2:13][CH2:12][O:11][C@@H:10]([CH2:14][OH:15])[CH2:9]1

参加物

3

反応物 2

HCID 1512576(R)-N-Boc-2-hydroxymethylmorpholine2 回HCID 1512577tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

生成物 1

HCID 40152301(R)-4-Methyl-2-(hydroxymethyl)morpholine

実験手順

(R)-(4-Methylmorpholin-2-yl)-methanol was prepared similar to the procedure described for Intermediate 10, but using (R)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 9) instead of (S)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 8). The title compound was obtained as a colourless oil (560 mg, 77%).

後処理

  1. custom(R)-(4-Methylmorpholin-2-yl)-methanol was prepared similar to the procedure

出典と根拠

ORDレコード
ord-9559d207592e41a0be638dc1a9a5e56d
出典データセット
uspto-grants-2010_12
特許番号
US07851471B2

反応ノート

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