5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole → 3-(3-Fluoro-phenyl)-5-trifluoromethyl-isoxazole
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:12][C:11]([C:14]([F:17])([F:16])[F:15])(O)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.C1(C2CC(O)(C(F)(F)F)ON=2)C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:12]=[C:11]([C:14]([F:15])([F:16])[F:17])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
As described for Example 1b, 3-(3-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol (60 g, 241 mmol), instead of 3-phenyl-5-hydroxy-5-(trifluoromethyl)isoxazoline, was converted to the title compound (47.5 g, 85%) which was obtained as a light brown solid. MS: m/e=231.1 [M]+.
出典と根拠
- ORDレコード
- ord-b4382e3342574a4e856447a4835b2022
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851469B2
反応ノート
読み込み中…