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Ethyl bromoacetate → (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one | HCID 69714 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester | HCID 15643798 | — |
反応手順
A mixture of 16.6 g (100.0 mmol) of 2-hydroxi-5-methoxyacetophenone, 20 g (208 mmol) of potassium carbonate, 16.7 g (100.0 mmol) of ethyl bromoacetate and 200 ml of MEK is stirred at reflux temperature for 10 hr. The solids are filtered and the filtrate concentrated. The residue is suspended in water and the solid is filtered and dried. Yield: 10.2 g (40%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557212B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-60bd36e5ee7d4e22abc36d0cbb75c24c |
| 出典メモ | uspto-grants-2009_07 |