Water → HCID 68776400、化合物

HRID 2262879ノート

反応式

HRID 2262879 の反応式
Cl[C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[N:3]=1.FC(F)(F)C(O)=O.[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[C:23]([NH:30][C:31]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[O:32])=[N:22]1.C(N(CC)CC)C.O>CN(C)C=O>[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[C:23]([NH:30][C:31]([N:33]2[CH2:38][CH2:37][N:36]([C:2]3[S:6][N:5]=[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[F:13])[N:3]=3)[CH2:35][CH2:34]2)=[O:32])=[N:22]1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 46318477HCID 46318477、化合物HCID 68778018N-1,2-Benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate

生成物 1

HCID 68776400HCID 68776400、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 5-chloro-3-(2-fluorophenyl)-1,2,4-thiadiazole (119 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured to water, and the desired product as a solid was separated by filtration, which was then recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran. Yield: 96.0 mg (40.9%).

後処理

  1. customthe desired product as a solid was separated by filtration, which
  2. customwas then recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran

出典と根拠

ORDレコード
ord-fe8e43d164a64751a671e1c5e5d5b41b
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

反応ノート

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