Sodium Hydroxide → 1-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine

関与物質

反応手順

1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride (1.00 g, 2.97 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (696 mg, 67.2%) as an oil.

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