関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 反応物 | 2,4-Difluorophenacyl thiocyanate | HCID 45036827 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole | HCID 53440970 | 73.6% |
反応手順
A 25% hydrogen bromide/acetic acid (25 ml) solution was added to a solution of 2-(2,4-difluorophenyl)-2-oxoethyl thiocyanate (3.39 g, 15.9 mmol) in acetic acid (25 ml), and the mixture was stirred at 130° C. for 2 hours and stirred at room temperature for 1 hour. Water was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 3.23 g (73.6%) of the desired product as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07851473B2 |
|---|
| 出典データセット | uspto-grants-2010_12 |
|---|
| ORD ID | ord-f544e0d9826a4c9e823ab4ed68037d1f |
|---|
| 出典メモ | uspto-grants-2010_12 |
|---|
