Bromine → 2-Bromo-1-(2,3-difluorophenyl)ethanone
反応式
[Br:1]Br.[F:3][C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[C:11](=[O:13])[CH3:12]>C(OCC)C>[Br:1][CH2:12][C:11]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([F:10])[C:4]=1[F:3])=[O:13]参加物
4
実験手順
Bromine (4.96 g, 31.1 mmol) was slowly added dropwise to a solution of 1-(2,3-difluorophenyl)ethanone (4.85 g, 31.1 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was distilled off under reduced pressure to give 7.29 g (99.9%) of the desired product as an oil.
後処理
- distillationThe reaction mixture was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-a9930742dd3f4d73bfeec6441ac181e8
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851473B2
反応ノート
読み込み中…