Water → 3-(2-Bromo-1,3-thiazol-4-yl)benzonitrile
反応式
[BrH:1].C(O)(=O)C.[C:6]([C:8]1[CH:9]=[C:10]([C:14](=O)[CH2:15][S:16][C:17]#[N:18])[CH:11]=[CH:12][CH:13]=1)#[N:7].O>C(O)(=O)C>[Br:1][C:17]1[S:16][CH:15]=[C:14]([C:10]2[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=2)[C:6]#[N:7])[N:18]=1参加物
5
反応条件
- 温度
- 130 °C
実験手順
A 25% hydrogen bromide/acetic acid (10 ml) solution was added to a solution of 2-(3-cyanophenyl)-2-oxoethyl thiocyanate (1.0 g, 4.94 mmol) in acetic acid (10 ml), and the mixture was stirred at 130° C. for 2 hours and at room temperature for 1 hour. Water was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 990 mg (75.6%) of the desired product as a solid.
後処理
- filtrationwere collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-578c4f1838ee4b16b1a1cedf610b6dcd
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851473B2
反応ノート
読み込み中…