Hydrochloric Acid → 1-[4-(3-Methylphenyl)-1,3-thiazol-2-yl]piperazine

HRID 2263305ノート

反応式

HRID 2263305 の反応式
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:6]=[CH:7][CH:8]=1>C(OCC)(=O)C>[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68778457HCID 68778457、化合物

生成物 1

HCID 617815611-[4-(3-Methylphenyl)-1,3-thiazol-2-yl]piperazine収率 63.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A 4 N solution (50 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(3-methylphenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (2.00 g, 5.56 mmol) in ethyl acetate (50 ml), the mixture was stirred at room temperature for 12 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 910 mg (62.9%) of the desired product as an oil.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-9080338f40fb469192b55ba9bcb7a7c4
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

反応ノート

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