Hydrochloric Acid → 2-Ethoxy-4-methoxybenzoic acid
反応式
C([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[O:13][CH2:14][CH3:15])C.[OH-].[K+].Cl>C(O)C>[CH2:14]([O:13][C:6]1[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=1[C:4]([OH:16])=[O:3])[CH3:15]参加物
5
実験手順
2-Ethoxy-4-methoxybenzoic acid ethyl ester (13 g, 58 mmol) was suspended in ethanol (150 mL). This was treated with potassium hydroxide (40 mL, ˜4 M) and refluxed for 1 h. The reaction was cooled and poured into cold aqueous hydrochloric acid (300 mL, 2 M) and extracted into dichloromethane (3×200 mL). The organic layers were washed with brine and dried over anhydrous magnesium sulfate. The solids were filtered off, and the filtrate was evaporated to dryness to give 2-ethoxy-4-methoxybenzoic acid (9.5 g, white solid).
後処理
- temperaturerefluxed for 1 h
- temperatureThe reaction was cooled
- extractionextracted into dichloromethane (3×200 mL)
- washThe organic layers were washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationThe solids were filtered off
- customthe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-6fd262c76ba342159226eab828976f53
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851626B2
反応ノート
読み込み中…