gamma-Hydroxypropyl ethyl sulfide → [(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone

関与物質

役割	名称	HCID	仕込み量
反応物	gamma-Hydroxypropyl ethyl sulfide	HCID 87762	—
反応物	1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride	HCID 49853479	—
反応物	(4R,5S)-2-(4-tert-Butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole	HCID 67071354	—
反応物	1-(3-Ethanesulfonyl-propyl)-piperazine dihydrochloride	HCID 67071500	—
生成物	[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone	HCID 58894220	—

反応手順

In a manner analogous to the method described in example 5, (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole (example 4) was reacted with 1-(3-ethanesulfonyl-propyl)-piperazine dihydrochloride (prepared from 3-ethylsulfanyl-propan-1-ol in an analogous manner as the method described for 1-(3-methanesulfonyl-propyl)-piperazine dihydrochloride) to give the title compound. HR-MS (ES, m/z) calculated for C39H51N4O4SCl2 [(M+H)+] 741.3003, observed 741.2998.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07851626B2
出典データセット	uspto-grants-2010_12
ORD ID	ord-9b9fbf6d6acd42659e0a064759230e44
出典メモ	uspto-grants-2010_12