Iodine → 6-Chloro-5-iodo-3-nitropyridin-2-amine

HRID 2264183ノート

反応式

HRID 2264183 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[I:12]

参加物

5

反応物 2

HCID 807IodineHCID 27240356-Chloro-3-nitropyridin-2-ylamine

生成物 1

HCID 595960036-Chloro-5-iodo-3-nitropyridin-2-amine収率 89.6%

試薬・触媒・溶媒 2

HCID 178418844HCID 178418844、化合物触媒HCID 702Ethanol溶媒

実験手順

To a suspension of 6-chloro-3-nitropyridin-2-amine (6.3 g, 36.3 mmol) in ethanol (110 mL), 9.2 g (36.3 mmol) of iodine and 11.32 g (36.3 mmol) of silver sulphate were added. The crude mixture was stirred at room temperature overnight and the precipitate formed was filtered off. The solid isolated was purified by flash chromatography (1:1 hexane/ethyl acetate) to give the title compound (9.74 g, 88% of yield).

後処理

  1. additionwere added
  2. customthe precipitate formed
  3. filtrationwas filtered off
  4. customThe solid isolated
  5. customwas purified by flash chromatography (1:1 hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-2f8338b6ffc44ad7941f251a7e41492a
出典データセット
uspto-grants-2010_12
特許番号
US07855202B2

反応ノート

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