関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,5-Difluoro-4-(tributylstannyl)pyridine | HCID 16427123 | — |
| 反応物 | 3-Bromo-5-nitro-2,3'-bipyridin-6-amine | HCID 59596002 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178479804 | HCID 178479804 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3'',5''-Difluoro-5'-nitro-3,2':3',4''-terpyridin-6'-amine | HCID 59595968 | — |
反応手順
A mixture of 3-bromo-5-nitro-2,3′-bipyridin-6-amine (Intermediate 1, step b, 1 g, 3.39 mmol), 3,5-difluoro-4-tributylstannanylpyridine (1.5 g, 3.71 mmol), bis(triphenylphosphino) palladium (II) chloride (0.24 g, 0.34 mmol) and copper (I) iodide (0.13 g, 0.68 mmol) in dioxane (15 mL) was heated at 150° C. for 6 hours in Biotage Initiator Microwave Synthesizer.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07855202B2 |
|---|
| 出典データセット | uspto-grants-2010_12 |
|---|
| ORD ID | ord-bbed566687474677817b5b53bff88c96 |
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| 出典メモ | uspto-grants-2010_12 |
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