Dimethylformamide → HCID 16118433、化合物

HRID 2264208ノート

反応式

HRID 2264208 の反応式
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[C:11]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[CH:10][C:9]([NH2:18])=[C:8]([NH2:19])[N:7]=1.C(N(CC)CC)C.CN(C)[CH:29]=[O:30]>>[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[N:7]=[C:8]2[NH:19][C:29](=[O:30])[NH:18][C:9]2=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 59595986HCID 59595986、化合物2 回

生成物 1

HCID 16118433HCID 16118433、化合物収率 45%

実験手順

A solution of 2-(1,3-oxazol-2-yl)-3,4′-bipyridine-5,6-diamine (Intermediate 10, 0.077 g, 0.3 mmol), N,N′-carbonyldiimidazole (0.146 g, 0.9 mmol) and triethylamine (91 mg, 0.9 mmol) in N,N-dimethylformamide (1 mL) was heated to 100° C. in a sealed tube. After 4 hours, the mixture was cooled and concentrated in vacuo. Water was added to the residue and the solid that separated was washed with water and dried to give the title compound (0.038 g, 45%) as a white solid.

後処理

  1. temperaturethe mixture was cooled
  2. concentrationconcentrated in vacuo
  3. additionWater was added to the residue
  4. customthe solid that separated
  5. washwas washed with water
  6. customdried

出典と根拠

ORDレコード
ord-4f670883641b495d8c2462d059301efb
出典データセット
uspto-grants-2010_12
特許番号
US07855202B2

反応ノート

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