Cyclopentylamine → 5-bromo-N-cyclopentyl-2-nitroaniline

HRID 2264362ノート

反応式

HRID 2264362 の反応式
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:8]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16]>C(O)CCC>[Br:14][C:12]1[CH:11]=[CH:10][C:9]([N+:15]([O-:17])=[O:16])=[C:8]([NH:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 123156462,4-Dibromo-1-nitrobenzene

生成物 1

HCID 653413535-bromo-N-cyclopentyl-2-nitroaniline

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

反応条件

温度
100 °C

実験手順

Add cyclopentanamine (32 mL) to a solution of 2,4-dibromo-1-nitro-benzene (20 g) in 1-butanol (160 mL). Heat the mixture at 100° C. overnight. Remove the solvent under vacuum, add water and extract with EA. Wash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate and then water. Dry over magnesium sulfate and remove the solvent under vacuum to afford 22 g of the title compound. MS (ES+): m/z=286 (M+H)+.

後処理

  1. customRemove the solvent under vacuum
  2. additionadd water
  3. extractionextract with EA
  4. washWash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate
  5. dry with materialDry over magnesium sulfate
  6. customremove the solvent under vacuum

出典と根拠

ORDレコード
ord-a3fe5ae5977840999ea2a400945b6900
出典データセット
uspto-grants-2010_12
特許番号
US07855211B2

反応ノート

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