Methyl Anthranilate → HCID 178515042、化合物

HRID 2264382ノート

反応式

HRID 2264382 の反応式
Cl[C:2]1[N:11]=[C:10]([O:12]CC)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:15](OC)(=[O:23])[C:16]1[C:17](=[CH:19][CH:20]=[CH:21][CH:22]=1)[NH2:18]>C(OCC)(=O)C>[OH:12][C:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]2[C:15](=[O:23])[C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=[C:2]2[N:11]=1

参加物

4

反応物 2

HCID 8635Methyl AnthranilateHCID 205064452-Chloro-4-ethoxyquinazoline

生成物 1

HCID 178515042HCID 178515042、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To the 2-chloro-4-ethoxy-quinazoline (500 mg, 2.40 mmol) in a boiling tube was added methyl anthranilate (372 μL, 2.88 mmol). The mixture was heated with a hot air gun (approx. 400 deg C.) for 15 minutes before cooling to room temperature. The resulting crude product was suspended in ethyl acetate (10 mL) and heated to boiling. The mixture was then cooled and the pure off-white product isolated by filtration (257 mg).

後処理

  1. temperatureThe mixture was heated with a hot air gun (approx. 400 deg C.) for 15 minutes
  2. temperatureheated to boiling
  3. temperatureThe mixture was then cooled
  4. customthe pure off-white product isolated by filtration (257 mg)

出典と根拠

ORDレコード
ord-2c411c15cc0f45d2bf4910cbcc1c2221
出典データセット
uspto-grants-2010_12
特許番号
US07855214B2

反応ノート

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