Hydrochloric Acid → HCID 178478869、化合物

HRID 2264425ノート

反応式

HRID 2264425 の反応式
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[N:18]=[C:17]([O:19]C)[CH:16]=[CH:15][N:14]=2)[CH2:8][CH2:7]1)=O)C.[ClH:21]>C(O)C>[ClH:21].[ClH:21].[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=2)[CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 24237580Ethyl 4-[(4-methoxypyrimidin-2-yl)amino]piperidine-1-carboxylate

生成物 1

HCID 178478869HCID 178478869、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4-(4-methoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.5 g, 5.35 mmol) in ethanol (50 mL) and conc. HCl (75 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 194.9 [M+H]+.

後処理

  1. temperatureto reflux for 18 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude product used in the consecutive step without further purification

出典と根拠

ORDレコード
ord-c15ad42c7ced438db05870c50bbf275b
出典データセット
uspto-grants-2010_12
特許番号
US07855194B2

反応ノート

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