化工社化工社 化学情報印刷レポート · 研究参考用
Water → 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 5-((6-Chloropyrimidin-4-yl)oxy)-1H-indole | HCID 57455156 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole | HCID 86234704 | — |
反応手順
490 mg (2.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) and 260 mg (4.0 mMol) NaN3 in 3 ml DMF are stirred for 3 h at 90° C. Then the reaction mixture is poured into water and extracted three times with EtOAc. The organic layers are washed twice with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: MS: [M+1]+=253.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07855215B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-15e27e7259fb44428da90c0ce67e12f8 |
| 出典メモ | uspto-grants-2010_12 |