化工社化工社 化学情報印刷レポート · 研究参考用
5-(6-Azido-pyrimidin-4-yloxy)-1H-indole → 5-(6-Amino-pyrimidin-4-yloxy)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole | HCID 86234704 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-(6-Amino-pyrimidin-4-yloxy)-1H-indole | HCID 21949266 | — |
反応手順
480 mg (1.9 mMol) 5-(6-azido-pyrimidin-4-yloxy)-1H-indole in 25 ml THF are hydrogenated in presence of 75 mg Pd/C 10%. Filtration, concentration of the filtrate and column chromatography (SiO2; EtOAc/hexane 3:1→EtOAc) gives the title compound: MS: [M+1]+=227; TLC(EtOAc): Rf=0.11
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07855215B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-44e175bf19d54bdb949918e394102f7a |
| 出典メモ | uspto-grants-2010_12 |