Hydrochloric Acid → HCID 68771648、化合物
反応式
C(OC(=O)[NH:7][C@H:8]([CH3:25])[C@@H:9]([O:17][Si](C(C)(C)C)(C)C)[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)(C)(C)C.Cl>CO>[ClH:16].[NH2:7][C@H:8]([CH3:25])[C@H:9]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[OH:17]参加物
4
実験手順
A solution of (1R,2S)-[2-(tert-butyl-dimethyl-silyloxy)-2-(4-chloro-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (354 mg, 0.88 mmol) in MeOH (10 mL) at rt was treated with HCl (4 M in dioxane, 3 mL). After 1 h, the mixture was concentrated to provide the desired amine as the hydrochloride salt (200 mg, quant.). 1H NMR (400 MHz, CD3OD): 7.43-7.37 (m, 4H), 4.91 (d, J=3.4, 1H), 3.50 (dq, J=6.8, 3.5, 1H), 1.07 (d, J=6.8, 3H).
後処理
- concentrationthe mixture was concentrated
出典と根拠
- ORDレコード
- ord-0ae8d87a7bdb4448bb163ecb2c3b929c
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07855292B2
反応ノート
読み込み中…