Hydrochloric Acid → 2,3-dihydro-1H-indene-5-carboxylic acid

HRID 22653

反応式

HRID 22653 の反応式
Cl[O-].[Na+].[CH2:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](=[O:15])C)=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.S(=O)(O)[O-:17].[Na+].Cl>O>[CH2:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:15])=[O:17])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 2339761-(2,3-Dihydro-1H-inden-5-yl)ethan-1-oneHCID 23665760Sodium HypochloriteHCID 23665763Sodium Bisulfite

生成物 1

HCID 2328412,3-dihydro-1H-indene-5-carboxylic acid収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
55 °C

実験手順

To a stirred 6% aqueous sodium hypochlorite solution in an oil bath to 55° C. is added 1-indane-5-yl-ethanone (1.0 g, 6.2 mmol). The solution is stirred at 55° C. for 2 h, followed by cooling to rt. Solid sodium bisulfite is added until the solution becomes clear. The mixture is diluted with water, followed by aqueous hydrochloric acid (6.0 M). The solid that forms is filtered and washed several times with water. The solid is dried under high vacuum at 60° C. for 5 h to afford 5-indancarboxylic acid as a white solid (0.96 g, 95%): 1H NMR (CDCl3) δ 8.0, 7.9, 7.3, 3.0, 2.1.

後処理

  1. temperatureby cooling to rt
  2. filtrationThe solid that forms is filtered
  3. washwashed several times with water
  4. customThe solid is dried under high vacuum at 60° C. for 5 h

出典と根拠

ORDレコード
ord-d2af36b00ad946f0b17305882efe727c
出典データセット
uspto-grants-2005_02
特許番号
US06849620B2

関連ノート

読み込み中…