HCID 10203347、化合物 → HCID 10154957、化合物

HRID 2265332ノート

反応式

HRID 2265332 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:23][CH2:24][CH2:25][O:26]C2CCCCO2)[C:11]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>C(O)(=O)C.C1COCC1.O>[OH:26][CH2:25][CH2:24][CH2:23][N:10]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=1)[C:11]([CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1)=[O:12]

参加物

3

反応物 1

HCID 10203347HCID 10203347、化合物

生成物 1

HCID 10154957HCID 10154957、化合物収率 62%

試薬・触媒・溶媒 1

HCID 21877175AcOH THF water溶媒

実験手順

N-(4-Isopropylphenyl)-N-[3-(tetrahydropyran-2-yloxy)propyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.24 g) was dissolved in a mixed solvent (7 mL) of acetic acid: THF: water (4:2:1) and stirred at room temperature for 2 hr. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give N-(3-hydroxypropyl)-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.12 g).

後処理

  1. customThe reaction mixture was partitioned between water and ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-4ab274ab77d04a19819a647ff3b91e06
出典データセット
uspto-grants-2010_12
特許番号
US07855297B2

反応ノート

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