3-Fluoro-5-(trifluoromethyl)benzeneboronic acid → HCID 57754974、化合物

HRID 226535ノート

反応式

HRID 226535 の反応式
[CH3:1][O:2][C:3](=[O:30])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=2)[CH:12]=[C:13]([OH:15])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:31][C:32]1[CH:33]=[C:34](B(O)O)[CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1>>[CH3:1][O:2][C:3](=[O:30])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[C:20]([C:22]([F:23])([F:25])[F:24])[CH:19]=[C:18]([C:26]([F:27])([F:28])[F:29])[CH:17]=2)[CH:12]=[C:13]([O:15][C:34]2[CH:35]=[C:36]([C:38]([F:40])([F:39])[F:41])[CH:37]=[C:32]([F:31])[CH:33]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

参加物

3

反応物 2

HCID 27831923-Fluoro-5-(trifluoromethyl)benzeneboronic acidHCID 577550022-(5-Hydroxy-3',5'-bis-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

生成物 1

HCID 57754974HCID 57754974、化合物収率 35%

実験手順

The title compound was prepared in 35% yield from 2-(5-hydroxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example C) and 3-fluoro-5-trifluoromethylphenyl-boronic acid under the conditions described in Example 15, step (g).

出典と根拠

ORDレコード
ord-075f0f45ab394af6abe93248da21bca4
出典データセット
uspto-grants-2009_07
特許番号
US07557244B2

反応ノート

読み込み中…