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2,5-Bis(trifluoromethyl)aniline → 2-[4'-Chloro-5-(2,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Bis(trifluoromethyl)aniline | HCID 719818 | — |
| 反応物 | 2-(4'-Chloro-5-trifluoromethanesulfonyloxy-3'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester | HCID 57754964 | — |
| 生成物 | 2-[4'-Chloro-5-(2,5-bis-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester | HCID 57755009 | 35% |
反応手順
The title compound was prepared in 35% yield from 2-(4′-chloro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 2,5-bis-(trifluoromethyl)aniline under the conditions described in Example 37, step (b).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557244B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-5d07c72995b346bf8a9c72bffe1a1a15 |
| 出典メモ | uspto-grants-2009_07 |