Water → HCID 66879234、化合物

HRID 2265888ノート

反応式

HRID 2265888 の反応式
[F:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25]C)(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br.O>ClCCl>[F:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[OH:25])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 66879518HCID 66879518、化合物

生成物 1

HCID 66879234HCID 66879234、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

620 mg (1.54 mmol) of 4-(4-fluorophenoxy)-N-[2-(2-methoxyphenyl)ethyl]benzene-sulfonamide are dissolved in 10 ml of dichloromethane and, at −40° C., 3.09 ml (3.09 mmol) of a 1 M solution of boron tribromide in dichloromethane are added. The solution is warmed to room temperature and stirred for a further four hours. It is subsequently added to water, the phases are separated, and the organic phase is washed twice more with H2O. The dichloromethane phase is dried with MgSO4 and concentrated, allowing the desired phenol to be isolated as a brown oil. Crude yield 89%.

後処理

  1. customthe phases are separated
  2. washthe organic phase is washed twice more with H2O
  3. dry with materialThe dichloromethane phase is dried with MgSO4
  4. concentrationconcentrated
  5. customto be isolated as a brown oil

出典と根拠

ORDレコード
ord-bd7d4d5013464bef9b121b3e7369f436
出典データセット
uspto-grants-2010_12
特許番号
US07858619B2

反応ノート

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