4-Fluoro-m-toluidine → 2-chloro-5-fluoro-N4-(4-fluoro-3-methylphenyl)-4-pyrimidineamine

HRID 226589

反応式

HRID 226589 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[F:10][C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][C:12]=1[CH3:18]>>[Cl:1][C:2]1[N:7]=[C:6]([NH:15][C:14]2[CH:16]=[CH:17][C:11]([F:10])=[C:12]([CH3:18])[CH:13]=2)[C:5]([F:9])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 679814-Fluoro-m-toluidineHCID 2507052,4-Dichloro-5-fluoropyrimidine

生成物 1

HCID 220605002-chloro-5-fluoro-N4-(4-fluoro-3-methylphenyl)-4-pyrimidineamine

実験手順

In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 4-fluoro-3-methylaniline were reacted to provide 2-chloro-5-fluoro-N4-(4-fluoro-3-methylphenyl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.06 (d, 1H, J=2.4 Hz), 7.48–7.43 (m, 1H), 7.39 (dd, 1H, J=2.7 and 6.3 Hz), 7.03 (t, 1H, J=9.0 Hz), 6.84 (bs, 1H), 2.30 (d, 1H, J=1.8 Hz); 19F NMR (282 MHz, CDCl3): −34285, −44676; LCMS: purity: 95%; MS (m/e): 257 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-fe4745f8efee4516b1613dd8b9a908c5
出典データセット
uspto-grants-2009_07
特許番号
US07557210B2

関連ノート

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