Potassium Carbonate → 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

HRID 2266142ノート

反応式

HRID 2266142 の反応式
[CH:1]([C:4]1[C:9](S(C2C=CC(C)=CC=2)(=O)=O)=[CH:8][C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[C:6]([O:25][CH3:26])[CH:5]=1)([CH3:3])[CH3:2].C([O-])([O-])=[O:28].[K+].[K+]>CO>[CH:1]([C:4]1[CH:5]=[C:6]([O:25][CH3:26])[C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[CH:8][C:9]=1[OH:28])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 595986244-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole

生成物 1

HCID 595986332-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-[4-Isopropyl-2-methoxy-5-(toluene4-sulfonyl)-phenyl]-thiazole (1.0 g, 2.27 mmol) and K2CO3 (1.6 g, 11.34 mmol) in anhydrous MeOH (10 ml) was refluxed for 8 hrs. Solvent was removed in vacuo and the residue was partitioned between methylene chloride and water. The combined organic extract was dried over Na2SO4, filtered, and concentrated to give 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol.

後処理

  1. temperaturewas refluxed for 8 hrs
  2. customSolvent was removed in vacuo
  3. customthe residue was partitioned between methylene chloride and water
  4. extractionThe combined organic extract
  5. dry with materialwas dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-e62df7319f2e41c8a2404a0b6e44cb55
出典データセット
uspto-grants-2010_12
特許番号
US07858632B2

反応ノート

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