Hydrochloric Acid → 4-(2-Amino-ethyl)-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide hydrochloride
反応式
[CH:1]([C:4]1[S:8][C:7]([NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21]C(=O)C)=[CH:15][CH:14]=2)(=[O:12])=[O:11])=[N:6][N:5]=1)([CH3:3])[CH3:2].[ClH:25]>>[ClH:25].[NH2:21][CH2:20][CH2:19][C:16]1[CH:17]=[CH:18][C:13]([S:10]([NH:9][C:7]2[S:8][C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][N:6]=2)(=[O:12])=[O:11])=[CH:14][CH:15]=1参加物
3
実験手順
16.8 g N-{2-[4-(5-Isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-ethyl}-acetamide was suspended in 120 ml one molar hydrochloric acid and heated under reflux for six hours. The cooled reaction mixture was evaporated in vacuo. The resulting residue was dissolved in 300 ml ethanol and dried over MgSO4. The ethanol was removed in vacuo to obtain 21.0 g 4-(2-Amino-ethyl)-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide hydrochloride as an amorphous solid, impurified with salts. This material was used without further purification.
後処理
- temperature