p-Anisoyl chloride → N-{2-[4-(5-isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-ethyl}-4-methoxy-benzamide
反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.Cl.[NH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:25][C:26]2[S:27][C:28]([CH:31]([CH3:33])[CH3:32])=[N:29][N:30]=2)(=[O:24])=[O:23])=[CH:18][CH:17]=1>ClCCl>[CH:31]([C:28]1[S:27][C:26]([NH:25][S:22]([C:19]2[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][NH:13][C:7](=[O:8])[C:6]3[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[CH:17][CH:18]=2)(=[O:24])=[O:23])=[N:30][N:29]=1)([CH3:33])[CH3:32]参加物
4
実験手順
21.4 mg 4-Methoxy-benzoyl chloride and 50 mg 4-(2-Amino-ethyl)-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-benzene sulfonamide hydrochloride were dissolved in 2 ml dichloromethane and stirred at room temperature for two hours. The reaction mixture was diluted by addition of 50 ml dichloromethane, washed three times with portions of 30 ml water and then dried over MgSO4. The solvent was removed in vacuo. The residue was purified by RP-HPLC to obtain 21.4 mg N-{2-[4-(5-isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-ethyl}-4-methoxy-benzamide.