p-Toluenesulfonic acid monohydrate → HCID 136335928、化合物

HRID 2266436ノート

反応式

HRID 2266436 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([O:15][CH:16]([C:20](=O)[CH3:21])[C:17](=O)[CH3:18])=[CH:13][CH:12]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:8][C:7]1[C:2]2[N:1]=[C:20]([CH3:21])[C:16]([O:15][C:14]3[CH:13]=[CH:12][C:11]([Cl:10])=[CH:24][CH:23]=3)=[C:17]([CH3:18])[C:3]=2[C:4]([OH:9])=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 521998p-Toluenesulfonic acid monohydrateHCID 27994473-(4-chlorophenoxy)pentane-2,4-dioneHCID 50700783-Amino-4-chlorophenol

生成物 1

HCID 136335928HCID 136335928、化合物

反応条件

温度
125 °C

実験手順

A mixture of 3-amino-4-chlorophenol (0.36 g), 3-(4-chlorophenoxy)pentane-2,4-dione (0.57 g) and p-toluenesulfonic acid monohydrate (0.020 g) was heated at 125° C. for 3 hours. The mixture was cooled to room temperature and purified by column chromatography on silica gel, eluting with a mixture of dichloromethane and ethyl acetate (1:0 to 0:1 by volume) to afford title compound as a brown oil, 0.16 g.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. custompurified by column chromatography on silica gel
  3. washeluting with a mixture of dichloromethane and ethyl acetate (1:0 to 0:1 by volume)

出典と根拠

ORDレコード
ord-d0597e3960964cdc9546e0718bc6934e
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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