関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 反応物 | 3-[(4-Chlorophenyl)methyl]pentane-2,4-dione | HCID 1488803 | — |
| 反応物 | 3-Amino-5-chlorophenol | HCID 19986947 | — |
| 反応物 | 5-Chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol | HCID 136335922 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 7-Chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol | HCID 136335902 | — |
反応手順
A mixture of 3-amino-5-chlorophenol (0.46 g), 3-(4-chlorobenzyl)pentane-2,4-dione (0.72 g), and p-toluenesulfonic acid monohydrate (0.26 g) was heated at 160° C. for 2 hours. The mixture was cooled to room temperature, diluted with methanol (5.0 mL) and sonicated. The resulting precipitate was collected by filtration, washed with methanol and dried to afford a 50:50 mixture of title compound and 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol as an off-white solid, 0.67 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07858640B2 |
|---|
| 出典データセット | uspto-grants-2010_12 |
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| ORD ID | ord-2eda990c044447b0b2d27e0e8d3449e5 |
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| 出典メモ | uspto-grants-2010_12 |
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