Methanesulfonic Acid → 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

HRID 2266501ノート

反応式

HRID 2266501 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[NH:9][C:10](=[O:26])[CH:11]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1)[C:12](=O)[CH3:13].CS(O)(=O)=O>C([O-])(=O)C.[Na+]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]2[C:3]=1[NH:9][C:10](=[O:26])[C:11]([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:20][CH:21]=1)=[C:12]2[CH3:13]

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 86631439N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide

生成物 1

HCID 687847618-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

試薬・触媒・溶媒 1

HCID 517045Sodium Acetate溶媒

反応条件

温度
100 °C

実験手順

A mixture of N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide (0.25 g) and methanesulfonic acid (1.1 g) was heated at 100° C. for 10 minutes. The mixture cooled to room temperature and poured into a saturated aqueous solution of sodium acetate (20 mL). The resulting precipitate was collected by filtration, washed with water and dried to afford title compound as a pale pink solid, 0.21 g.

後処理

  1. temperatureThe mixture cooled to room temperature
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-c3b35f5ecd144c3199fae07c69245444
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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