Acetic Acid → N-(2-fluoro-5-nitrophenyl)acetamide

HRID 2266558ノート

反応式

HRID 2266558 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[NH2:18].C(O)(=O)C>O>[F:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[NH:18][C:5](=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 677852-Fluoro-5-nitroaniline

生成物 1

HCID 2779405N-(2-fluoro-5-nitrophenyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

Acetic anhydride (8.0 mL) was added dropwise over a period of 10 minutes to a mixture of 2-fluoro-5-nitrophenylamine (7.8 g) and acetic acid (50 mL) at reflux. The resulting mixture was heated at reflux for 30 minutes and cooled to 40° C. The mixture was poured into cold water (800 mL) and the resulting precipitate collected by filtration, washed with 1.0 M aqueous hydrochloric acid and water and dried to give title compound as a light brown solid, 9.2 g.

後処理

  1. temperatureat reflux
  2. temperatureThe resulting mixture was heated
  3. temperatureat reflux for 30 minutes
  4. filtrationthe resulting precipitate collected by filtration
  5. washwashed with 1.0 M aqueous hydrochloric acid and water
  6. customdried

出典と根拠

ORDレコード
ord-08fed089b01c4df39708421871d8ce18
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

読み込み中…